Loss of IGF2R indicates a poor prognosis and promotes cell proliferation and tumorigenesis in bladder cancer via AKT signaling pathway

Loss of IGF2R indicates a poor prognosis and promotes cell proliferation and tumorigenesis in bladder cancer via AKT signaling pathway

The insulin growth factor 2 receptor (IGF2R) belongs to insulin growth factor (IGF) pathway and has been proposed as the tumor suppressor in many cancers. However, its role in bladder cancer is unknown. In the current study, we reported that IGF2R expression was decreased in bladder cancer tissues (...

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Veröffentlicht in:Neoplasma 2020-01, Vol.67 (1), p.129-136
Hauptverfasser: Liu, S B, Zhou, L B, Wang, H F, Li, G, Xie, Q P, Hu, B
Format: Artikel
Sprache:eng
Schlagworte:
Carcinogenesis
Cell Line, Tumor
Cell Proliferation
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Genes, Tumor Suppressor
Humans
Phosphorylation
Prognosis
Proto-Oncogene Proteins c-akt - metabolism
Receptor, IGF Type 2 - genetics
Signal Transduction
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
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Zusammenfassung:The insulin growth factor 2 receptor (IGF2R) belongs to insulin growth factor (IGF) pathway and has been proposed as the tumor suppressor in many cancers. However, its role in bladder cancer is unknown. In the current study, we reported that IGF2R expression was decreased in bladder cancer tissues (p
ISSN:0028-2685
1338-4317
1338-4317
DOI:10.4149/neo_2019_190206N108