Large solitary lytic skull vault lesions in adults: radiological review with pathological correlation

The diagnosis of a large solitary lytic skull vault lesion in adults is a challenge due to variable aggressiveness and overlapping features. The purpose of this article is to demonstrate the use of an imaging approach to narrow the differential diagnosis when a large solitary lytic skull vault lesion is encountered. The initial imaging assessment using computed tomography (CT) is invaluable in determining lesion aggressiveness based on bony margins and skull tables involvement. Further assessment with magnetic resonance (MR) imaging including diffusion weighted imaging (DWI) aids in soft tissue characterization. We present cases of large solitary lytic skull vault lesions in adults, emphasizing on salient and atypical imaging features, with pathological correlation for better understanding of the disease processes that underlie the imaging features. •Evaluation of solitary lytic skull vault lesion using a CT diagnostic algorithm is discussed.•The utility of MRI with DWI aids in characterization of the soft tissue component.•Imaging correlation with pathological features improves understanding of the disease processes.