Does celiac disease impair coronary microvascular circulation: Coronary flow velocity reserve of patients with celiac disease
Background Celiac disease (CD) is an enteropathy characterized with immune reaction to gliadin protein. Aim In this study, we aimed to assess effect of CD on coronary microvascular circulation and the association between coronary flow velocity reserve (CFVR) and hs‐CRP/Albumin ratio. Material and Me...
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| Veröffentlicht in: | Echocardiography (Mount Kisco, N.Y.) N.Y.), 2020-01, Vol.37 (1), p.34-40 |
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| container_title | Echocardiography (Mount Kisco, N.Y.) |
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| creator | Caliskan, Zuhal Telci Caklili, Ozge Kahraman, Resul Ozcan, Fatma Betul Sayar, Suleyman Kostek, Osman Demircioglu, Kenan Yilmaz, Yusuf Kul, Seref Caliskan, Mustafa |
| description | Background
Celiac disease (CD) is an enteropathy characterized with immune reaction to gliadin protein.
Aim
In this study, we aimed to assess effect of CD on coronary microvascular circulation and the association between coronary flow velocity reserve (CFVR) and hs‐CRP/Albumin ratio.
Material and Methods
Study was conducted between March 2017 and November 2018 with CD at Umraniye Training and Research Hospital Gastroenterology Clinic. CFVR was defined as the ratio of hyperemic to baseline diastolic peak velocities. CFVR ≥ 2.0 was considered normal. C‐reactive protein/albumin ratio (CAR) was calculated as hs‐CRP/albumin.
Results
Serum albumin (4.27 ± 0.56 vs 4.50 ± 0.34; P value: .04) level was significantly lower in celiac group but higher Hs‐CRP (2.44 ± 1.24 vs 1.82 ± 1.29; P value |
| doi_str_mv | 10.1111/echo.14554 |
| format | Article |
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Celiac disease (CD) is an enteropathy characterized with immune reaction to gliadin protein.
Aim
In this study, we aimed to assess effect of CD on coronary microvascular circulation and the association between coronary flow velocity reserve (CFVR) and hs‐CRP/Albumin ratio.
Material and Methods
Study was conducted between March 2017 and November 2018 with CD at Umraniye Training and Research Hospital Gastroenterology Clinic. CFVR was defined as the ratio of hyperemic to baseline diastolic peak velocities. CFVR ≥ 2.0 was considered normal. C‐reactive protein/albumin ratio (CAR) was calculated as hs‐CRP/albumin.
Results
Serum albumin (4.27 ± 0.56 vs 4.50 ± 0.34; P value: .04) level was significantly lower in celiac group but higher Hs‐CRP (2.44 ± 1.24 vs 1.82 ± 1.29; P value < .01), hs‐CRP/albumin ratio (0.57 ± 0.30 vs 0.41 ± 0.31; P value: .03) were recorded in celiac group. Both hyperemic flow and CFVR substantially lower in the celiac group compared to controls. In univariate analysis; age, hs‐CRP, and hs‐CRP/albumin ratio were associated with low CFVR and hs‐CRP/albumin level was an accurate predictor of low CFVR at the ROC curve.
Conclusion
In this study, we found that in patients with CD, coronary flow reserve is impaired.</description><identifier>ISSN: 0742-2822</identifier><identifier>EISSN: 1540-8175</identifier><identifier>DOI: 10.1111/echo.14554</identifier><identifier>PMID: 31816123</identifier><language>eng</language><publisher>United States</publisher><subject>atherosclerosis ; celiac disease ; coronary flow velocity reserve</subject><ispartof>Echocardiography (Mount Kisco, N.Y.), 2020-01, Vol.37 (1), p.34-40</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3294-f14be257a79b5def8c8064984142f2b8ccb2cb17e2d64e9aba7a7ce5f500c7593</citedby><cites>FETCH-LOGICAL-c3294-f14be257a79b5def8c8064984142f2b8ccb2cb17e2d64e9aba7a7ce5f500c7593</cites><orcidid>0000-0001-7566-5427</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fecho.14554$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fecho.14554$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31816123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caliskan, Zuhal</creatorcontrib><creatorcontrib>Telci Caklili, Ozge</creatorcontrib><creatorcontrib>Kahraman, Resul</creatorcontrib><creatorcontrib>Ozcan, Fatma Betul</creatorcontrib><creatorcontrib>Sayar, Suleyman</creatorcontrib><creatorcontrib>Kostek, Osman</creatorcontrib><creatorcontrib>Demircioglu, Kenan</creatorcontrib><creatorcontrib>Yilmaz, Yusuf</creatorcontrib><creatorcontrib>Kul, Seref</creatorcontrib><creatorcontrib>Caliskan, Mustafa</creatorcontrib><title>Does celiac disease impair coronary microvascular circulation: Coronary flow velocity reserve of patients with celiac disease</title><title>Echocardiography (Mount Kisco, N.Y.)</title><addtitle>Echocardiography</addtitle><description>Background
Celiac disease (CD) is an enteropathy characterized with immune reaction to gliadin protein.
Aim
In this study, we aimed to assess effect of CD on coronary microvascular circulation and the association between coronary flow velocity reserve (CFVR) and hs‐CRP/Albumin ratio.
Material and Methods
Study was conducted between March 2017 and November 2018 with CD at Umraniye Training and Research Hospital Gastroenterology Clinic. CFVR was defined as the ratio of hyperemic to baseline diastolic peak velocities. CFVR ≥ 2.0 was considered normal. C‐reactive protein/albumin ratio (CAR) was calculated as hs‐CRP/albumin.
Results
Serum albumin (4.27 ± 0.56 vs 4.50 ± 0.34; P value: .04) level was significantly lower in celiac group but higher Hs‐CRP (2.44 ± 1.24 vs 1.82 ± 1.29; P value < .01), hs‐CRP/albumin ratio (0.57 ± 0.30 vs 0.41 ± 0.31; P value: .03) were recorded in celiac group. Both hyperemic flow and CFVR substantially lower in the celiac group compared to controls. In univariate analysis; age, hs‐CRP, and hs‐CRP/albumin ratio were associated with low CFVR and hs‐CRP/albumin level was an accurate predictor of low CFVR at the ROC curve.
Conclusion
In this study, we found that in patients with CD, coronary flow reserve is impaired.</description><subject>atherosclerosis</subject><subject>celiac disease</subject><subject>coronary flow velocity reserve</subject><issn>0742-2822</issn><issn>1540-8175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp90EFPwyAYBmBiNG5OL_4Aw9GYdAKFtfVm6nQmS3bRc0Pp1wzTlgrtlh387zK7efAgFwh58sL3InRNyZT6dQ9qbaaUC8FP0JgKToKYRuIUjUnEWcBixkbowrkPQkhEKT9Ho5DGdEZZOEZfTwYcVlBpqXChHUgHWNet1BYrY00j7Q7XWlmzkU71lfTX2u4PnTbNA06PpqzMFm-gMkp3O2zBgd0ANiVuvYSmc3iru_Wfly7RWSkrB1eHfYLen-dv6SJYrl5e08dloEKW8KCkPAcmIhkluSigjFVMZjyJOeWsZHmsVM5UTiNgxYxDInPpqQJRCkJUJJJwgm6H3Naazx5cl9Xa-a9UsgHTu4yFLORRIhjz9G6gfmTnLJRZa3XtJ8woyfZ1Z_u6s5-6Pb455PZ5DcUvPfbrAR3AVlew-ycqm6eL1RD6DVmijYQ</recordid><startdate>202001</startdate><enddate>202001</enddate><creator>Caliskan, Zuhal</creator><creator>Telci Caklili, Ozge</creator><creator>Kahraman, Resul</creator><creator>Ozcan, Fatma Betul</creator><creator>Sayar, Suleyman</creator><creator>Kostek, Osman</creator><creator>Demircioglu, Kenan</creator><creator>Yilmaz, Yusuf</creator><creator>Kul, Seref</creator><creator>Caliskan, Mustafa</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7566-5427</orcidid></search><sort><creationdate>202001</creationdate><title>Does celiac disease impair coronary microvascular circulation: Coronary flow velocity reserve of patients with celiac disease</title><author>Caliskan, Zuhal ; Telci Caklili, Ozge ; Kahraman, Resul ; Ozcan, Fatma Betul ; Sayar, Suleyman ; Kostek, Osman ; Demircioglu, Kenan ; Yilmaz, Yusuf ; Kul, Seref ; Caliskan, Mustafa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3294-f14be257a79b5def8c8064984142f2b8ccb2cb17e2d64e9aba7a7ce5f500c7593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>atherosclerosis</topic><topic>celiac disease</topic><topic>coronary flow velocity reserve</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caliskan, Zuhal</creatorcontrib><creatorcontrib>Telci Caklili, Ozge</creatorcontrib><creatorcontrib>Kahraman, Resul</creatorcontrib><creatorcontrib>Ozcan, Fatma Betul</creatorcontrib><creatorcontrib>Sayar, Suleyman</creatorcontrib><creatorcontrib>Kostek, Osman</creatorcontrib><creatorcontrib>Demircioglu, Kenan</creatorcontrib><creatorcontrib>Yilmaz, Yusuf</creatorcontrib><creatorcontrib>Kul, Seref</creatorcontrib><creatorcontrib>Caliskan, Mustafa</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caliskan, Zuhal</au><au>Telci Caklili, Ozge</au><au>Kahraman, Resul</au><au>Ozcan, Fatma Betul</au><au>Sayar, Suleyman</au><au>Kostek, Osman</au><au>Demircioglu, Kenan</au><au>Yilmaz, Yusuf</au><au>Kul, Seref</au><au>Caliskan, Mustafa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does celiac disease impair coronary microvascular circulation: Coronary flow velocity reserve of patients with celiac disease</atitle><jtitle>Echocardiography (Mount Kisco, N.Y.)</jtitle><addtitle>Echocardiography</addtitle><date>2020-01</date><risdate>2020</risdate><volume>37</volume><issue>1</issue><spage>34</spage><epage>40</epage><pages>34-40</pages><issn>0742-2822</issn><eissn>1540-8175</eissn><abstract>Background
Celiac disease (CD) is an enteropathy characterized with immune reaction to gliadin protein.
Aim
In this study, we aimed to assess effect of CD on coronary microvascular circulation and the association between coronary flow velocity reserve (CFVR) and hs‐CRP/Albumin ratio.
Material and Methods
Study was conducted between March 2017 and November 2018 with CD at Umraniye Training and Research Hospital Gastroenterology Clinic. CFVR was defined as the ratio of hyperemic to baseline diastolic peak velocities. CFVR ≥ 2.0 was considered normal. C‐reactive protein/albumin ratio (CAR) was calculated as hs‐CRP/albumin.
Results
Serum albumin (4.27 ± 0.56 vs 4.50 ± 0.34; P value: .04) level was significantly lower in celiac group but higher Hs‐CRP (2.44 ± 1.24 vs 1.82 ± 1.29; P value < .01), hs‐CRP/albumin ratio (0.57 ± 0.30 vs 0.41 ± 0.31; P value: .03) were recorded in celiac group. Both hyperemic flow and CFVR substantially lower in the celiac group compared to controls. In univariate analysis; age, hs‐CRP, and hs‐CRP/albumin ratio were associated with low CFVR and hs‐CRP/albumin level was an accurate predictor of low CFVR at the ROC curve.
Conclusion
In this study, we found that in patients with CD, coronary flow reserve is impaired.</abstract><cop>United States</cop><pmid>31816123</pmid><doi>10.1111/echo.14554</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7566-5427</orcidid></addata></record> |
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| issn | 0742-2822 1540-8175 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals |
| subjects | atherosclerosis celiac disease coronary flow velocity reserve |
| title | Does celiac disease impair coronary microvascular circulation: Coronary flow velocity reserve of patients with celiac disease |
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