Dynamic thiol/disulphide homeostasis in patients with hypertrophic cardiomyopathy

Background In addition to the genetic complexity of hypertrophic cardiomyopathy (HCM), there must be other disease-modifying factors that contribute to its highly variable clinical and phenotypic expression. The authors aimed to investigate serum thiol/disulphide homeostasis as a proxy for oxidative stress using a novel automated assay in patients with HCM. Methods This cross-sectional study was conducted on 119 patients with HCM and 52 without HCM. The methods used to measure dynamic thiol/disulphide homeostasis as calorimetric and duplex quantities were developed in 2014. Results Median serum native thiol levels were significantly lower in patients with HCM than in those without (312.5 μmol/L [285–370 μmol/L] vs 421 μmol/L [349–469.5 μmol/L]; p