C-lection by the DM15 Motif Gets LARP1 to the TOP

C-lection by the DM15 Motif Gets LARP1 to the TOP

LARP1 proteins integrate the translation and stability of 5′TOP mRNAs with signaling from the mTOR pathway, but the mechanism is not well understood. In this issue of Structure, Cassidy et al. (2019) propose that the LARP1-DM15 motif modulates access to the 5′TOP mRNA’s m7G-ppp-Cytosine cap. LARP1 p...

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Veröffentlicht in:Structure (London) 2019-12, Vol.27 (12), p.1737-1739
Hauptverfasser: Bayfield, Mark A., Kerkhofs, Kyra, Mansouri-Noori, Farnaz
Format: Artikel
Sprache:eng
Schlagworte:
Autoantigens
Ribonucleoproteins
RNA, Messenger
Signal Transduction
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Zusammenfassung:LARP1 proteins integrate the translation and stability of 5′TOP mRNAs with signaling from the mTOR pathway, but the mechanism is not well understood. In this issue of Structure, Cassidy et al. (2019) propose that the LARP1-DM15 motif modulates access to the 5′TOP mRNA’s m7G-ppp-Cytosine cap. LARP1 proteins integrate the translation and stability of 5′TOP mRNAs with signaling from the mTOR pathway, but the mechanism is not well understood. In this issue of Structure, Cassidy et al. (2019) propose that the LARP1-DM15 motif modulates access to the 5′TOP mRNA’s m7G-ppp-Cytosine cap.
ISSN:0969-2126
1878-4186
DOI:10.1016/j.str.2019.11.010