Blue Light Induced Difluoroalkylation of Alkynes and Alkenes

Blue Light Induced Difluoroalkylation of Alkynes and Alkenes

The difluoroalkylation of alkynes and alkenes by direct photoexcitation of ethyl difluoroiodoacetate is described. Under catalyst- and oxidant-free conditions, iododifluoro­alkylation and hydrodifluoro­alkylation products were generated from alkynes, and difluoroalkylation products were prepared fro...

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Veröffentlicht in:Organic letters 2019-12, Vol.21 (24), p.9914-9918
Hauptverfasser: Li, Kangkui, Zhang, Xuexin, Chen, Jingchao, Gao, Yang, Yang, Chunhui, Zhang, Keyang, Zhou, Yongyun, Fan, Baomin
Format: Artikel
Sprache:eng
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Zusammenfassung:The difluoroalkylation of alkynes and alkenes by direct photoexcitation of ethyl difluoroiodoacetate is described. Under catalyst- and oxidant-free conditions, iododifluoro­alkylation and hydrodifluoro­alkylation products were generated from alkynes, and difluoroalkylation products were prepared from alkenes. This methodology provides a streamlined access to difluoroalkylated organic compounds starting from simple alkynes or alkenes.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03855