Phage combination therapies for bacterial wilt disease in tomato
Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanace...
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Veröffentlicht in: | Nature biotechnology 2019-12, Vol.37 (12), p.1513-1520 |
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creator | Wang, Xiaofang Wei, Zhong Yang, Keming Wang, Jianing Jousset, Alexandre Xu, Yangchun Shen, Qirong Friman, Ville-Petri |
description | Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on
Ralstonia solanacearum
infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward
R. solanacearum
. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.
Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%. |
doi_str_mv | 10.1038/s41587-019-0328-3 |
format | Article |
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Ralstonia solanacearum
infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward
R. solanacearum
. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.
Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/s41587-019-0328-3</identifier><identifier>PMID: 31792408</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/158/1745 ; 631/158/2456 ; 631/158/855 ; 631/326/2565/2134 ; 631/61/168 ; Agriculture ; Bacteria ; Bacterial diseases of plants ; Bacterial infections ; Bacteriophages ; Bacteriophages - genetics ; Bioinformatics ; Biological control ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; Care and treatment ; Diseases and pests ; Environmental aspects ; Field tests ; Health aspects ; Incidence ; Life Sciences ; Lycopersicon esculentum - microbiology ; Microbiomes ; Microbiota ; Microbiota (Symbiotic organisms) ; Pathogens ; Pest Control, Biological - methods ; Pesticides ; Pests ; Phages ; Plant Diseases - microbiology ; Ralstonia solanacearum - genetics ; Ralstonia solanacearum - pathogenicity ; Ralstonia solanacearum - virology ; Rhizosphere ; Tomatoes ; Wilt</subject><ispartof>Nature biotechnology, 2019-12, Vol.37 (12), p.1513-1520</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2019</rights><rights>COPYRIGHT 2019 Nature Publishing Group</rights><rights>COPYRIGHT 2019 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Dec 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c577t-ec7ec740b8b8f41065763e0c74a4b678aa81078e5b42915b6deabe81dc83b6983</citedby><cites>FETCH-LOGICAL-c577t-ec7ec740b8b8f41065763e0c74a4b678aa81078e5b42915b6deabe81dc83b6983</cites><orcidid>0000-0002-7967-4897 ; 0000-0002-4939-2506 ; 0000-0002-1592-157X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41587-019-0328-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41587-019-0328-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31792408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaofang</creatorcontrib><creatorcontrib>Wei, Zhong</creatorcontrib><creatorcontrib>Yang, Keming</creatorcontrib><creatorcontrib>Wang, Jianing</creatorcontrib><creatorcontrib>Jousset, Alexandre</creatorcontrib><creatorcontrib>Xu, Yangchun</creatorcontrib><creatorcontrib>Shen, Qirong</creatorcontrib><creatorcontrib>Friman, Ville-Petri</creatorcontrib><title>Phage combination therapies for bacterial wilt disease in tomato</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on
Ralstonia solanacearum
infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward
R. solanacearum
. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.
Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.</description><subject>631/158/1745</subject><subject>631/158/2456</subject><subject>631/158/855</subject><subject>631/326/2565/2134</subject><subject>631/61/168</subject><subject>Agriculture</subject><subject>Bacteria</subject><subject>Bacterial diseases of plants</subject><subject>Bacterial infections</subject><subject>Bacteriophages</subject><subject>Bacteriophages - genetics</subject><subject>Bioinformatics</subject><subject>Biological control</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering/Biotechnology</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Care and treatment</subject><subject>Diseases and pests</subject><subject>Environmental aspects</subject><subject>Field tests</subject><subject>Health aspects</subject><subject>Incidence</subject><subject>Life Sciences</subject><subject>Lycopersicon esculentum - microbiology</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microbiota (Symbiotic organisms)</subject><subject>Pathogens</subject><subject>Pest Control, Biological - methods</subject><subject>Pesticides</subject><subject>Pests</subject><subject>Phages</subject><subject>Plant Diseases - microbiology</subject><subject>Ralstonia solanacearum - genetics</subject><subject>Ralstonia solanacearum - pathogenicity</subject><subject>Ralstonia solanacearum - 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combination therapies for bacterial wilt disease in tomato</title><author>Wang, Xiaofang ; Wei, Zhong ; Yang, Keming ; Wang, Jianing ; Jousset, Alexandre ; Xu, Yangchun ; Shen, Qirong ; Friman, Ville-Petri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c577t-ec7ec740b8b8f41065763e0c74a4b678aa81078e5b42915b6deabe81dc83b6983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>631/158/1745</topic><topic>631/158/2456</topic><topic>631/158/855</topic><topic>631/326/2565/2134</topic><topic>631/61/168</topic><topic>Agriculture</topic><topic>Bacteria</topic><topic>Bacterial diseases of plants</topic><topic>Bacterial infections</topic><topic>Bacteriophages</topic><topic>Bacteriophages - genetics</topic><topic>Bioinformatics</topic><topic>Biological control</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedical 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Biotechnol</addtitle><date>2019-12-01</date><risdate>2019</risdate><volume>37</volume><issue>12</issue><spage>1513</spage><epage>1520</epage><pages>1513-1520</pages><issn>1087-0156</issn><eissn>1546-1696</eissn><abstract>Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on
Ralstonia solanacearum
infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward
R. solanacearum
. Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria.
Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>31792408</pmid><doi>10.1038/s41587-019-0328-3</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7967-4897</orcidid><orcidid>https://orcid.org/0000-0002-4939-2506</orcidid><orcidid>https://orcid.org/0000-0002-1592-157X</orcidid><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; SpringerLink Journals; Nature Journals Online |
subjects | 631/158/1745 631/158/2456 631/158/855 631/326/2565/2134 631/61/168 Agriculture Bacteria Bacterial diseases of plants Bacterial infections Bacteriophages Bacteriophages - genetics Bioinformatics Biological control Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Care and treatment Diseases and pests Environmental aspects Field tests Health aspects Incidence Life Sciences Lycopersicon esculentum - microbiology Microbiomes Microbiota Microbiota (Symbiotic organisms) Pathogens Pest Control, Biological - methods Pesticides Pests Phages Plant Diseases - microbiology Ralstonia solanacearum - genetics Ralstonia solanacearum - pathogenicity Ralstonia solanacearum - virology Rhizosphere Tomatoes Wilt |
title | Phage combination therapies for bacterial wilt disease in tomato |
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