Phage combination therapies for bacterial wilt disease in tomato

Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanace...

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Veröffentlicht in:Nature biotechnology 2019-12, Vol.37 (12), p.1513-1520
Hauptverfasser: Wang, Xiaofang, Wei, Zhong, Yang, Keming, Wang, Jianing, Jousset, Alexandre, Xu, Yangchun, Shen, Qirong, Friman, Ville-Petri
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container_end_page 1520
container_issue 12
container_start_page 1513
container_title Nature biotechnology
container_volume 37
creator Wang, Xiaofang
Wei, Zhong
Yang, Keming
Wang, Jianing
Jousset, Alexandre
Xu, Yangchun
Shen, Qirong
Friman, Ville-Petri
description Bacteriophages have been proposed as an alternative to pesticides to kill bacterial pathogens of crops. However, the efficacy of phage biocontrol is variable and poorly understood in natural rhizosphere microbiomes. We studied biocontrol efficacy of different phage combinations on Ralstonia solanacearum infection in tomato. Increasing the number of phages in combinations decreased the incidence of disease by up to 80% in greenhouse and field experiments during a single crop season. The decreased incidence of disease was explained by a reduction in pathogen density and the selection for phage-resistant but slow-growing pathogen strains, together with enrichment for bacterial species that were antagonistic toward R. solanacearum . Phage treatment did not affect the existing rhizosphere microbiota. Specific phage combinations have potential as precision tools to control plant pathogenic bacteria. Phage combination therapies reduce bacterial wilt disease incidence in tomato by up to 80%.
doi_str_mv 10.1038/s41587-019-0328-3
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subjects 631/158/1745
631/158/2456
631/158/855
631/326/2565/2134
631/61/168
Agriculture
Bacteria
Bacterial diseases of plants
Bacterial infections
Bacteriophages
Bacteriophages - genetics
Bioinformatics
Biological control
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Care and treatment
Diseases and pests
Environmental aspects
Field tests
Health aspects
Incidence
Life Sciences
Lycopersicon esculentum - microbiology
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Pathogens
Pest Control, Biological - methods
Pesticides
Pests
Phages
Plant Diseases - microbiology
Ralstonia solanacearum - genetics
Ralstonia solanacearum - pathogenicity
Ralstonia solanacearum - virology
Rhizosphere
Tomatoes
Wilt
title Phage combination therapies for bacterial wilt disease in tomato
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