Four New Diterpenoid Alkaloids from The Roots of Aconitum coreanum

Four new hetisine‐type C20‐diterpenoid alkaloids, named as coreanines A–D (1–4), were isolated from the roots of Aconitum coreanum, together with thirteen known alkaloids (5–17). Their structures were elucidated by extensive spectroscopic methods including IR, HR‐ESI‐MS and NMR techniques. All the i...

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Veröffentlicht in:	Chemistry & biodiversity 2020-01, Vol.17 (1), p.e1900600-n/a
Hauptverfasser:	Xu, Jin‐Bu, Luo, Yan‐Yan, Huang, Shuai, Gao, Feng, Zhou, Xian‐Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Aconitum Aconitum - chemistry Aconitum coreanum Alkaloids Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Animals C20-diterpenoid alkaloids Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology coreanines A–D Diterpenes Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Electrophorus Molecular Structure NMR Nuclear magnetic resonance phytochemistry Plant Roots - chemistry Ranunculaceae Roots
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Beschreibung
Zusammenfassung:	Four new hetisine‐type C20‐diterpenoid alkaloids, named as coreanines A–D (1–4), were isolated from the roots of Aconitum coreanum, together with thirteen known alkaloids (5–17). Their structures were elucidated by extensive spectroscopic methods including IR, HR‐ESI‐MS and NMR techniques. All the isolated compounds were screened for the acetylcholinesterase (AChE) inhibitory effects, and none of them showed considerable inhibitory activity.
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.201900600