A Strategy for the Synthesis of Sulfonamides on DNA

A Strategy for the Synthesis of Sulfonamides on DNA

An efficient method is reported to synthesize sulfonamides on DNA from sulfinic acids or sodium sulfinates and amines in the presence of iodine under mild conditions. This method demonstrates a major expansion of scope of sulfonamide formation on DNA through the utilization of a novel sodium carbona...

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Veröffentlicht in:Organic letters 2019-12, Vol.21 (24), p.9909-9913
Hauptverfasser: Liu, Wei, Deng, Wei, Sun, Saisai, Yu, Chunyan, Su, Xubo, Wu, Aliang, Yuan, Youlang, Ma, Zhonglin, Li, Ke, Yang, Hongfang, Peng, Xuanjia, Dietrich, Justin
Format: Artikel
Sprache:eng
Schlagworte:
Amines - chemistry
DNA - chemistry
Iodine - chemistry
Molecular Structure
Sulfinic Acids - chemistry
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
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Beschreibung
Zusammenfassung:An efficient method is reported to synthesize sulfonamides on DNA from sulfinic acids or sodium sulfinates and amines in the presence of iodine under mild conditions. This method demonstrates a major expansion of scope of sulfonamide formation on DNA through the utilization of a novel sodium carbonate–sodium sulfinate bifunctional reagent class.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03843