Rapid haemodilution accelerates hypertonicity resolution in diabetic ketoacidosis: Data from 25 intensive care admissions

Background: Clinically apparent cerebral oedema during diabetic ketoacidosis (DKA) is rare and more common in children and young adults. Subclinical oedema with mild brain dysfunction is more frequent, with unknown long term effects. Rapid tonicity changes may be a factor although not well studied....

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Veröffentlicht in:	Critical care and resuscitation 2019-12, Vol.21 (4), p.274-283
Hauptverfasser:	Morgan, Thomas J, Scott, Peter J, Anstey, Christopher M
Format:	Artikel
Sprache:	eng
Schlagworte:	Admission and discharge Blood Glucose - metabolism Cerebral edema Child Critical Care - methods Critical Illness - therapy Diabetic acidosis Diabetic Ketoacidosis - blood Diabetic Ketoacidosis - metabolism Diabetic Ketoacidosis - therapy Emergency Service, Hospital - organization & administration Hemodilution Hospital patients Hospitalization Humans Intensive care units Intensive Care Units - organization & administration Mortality Retrospective Studies Young Adult
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Zusammenfassung:	Background: Clinically apparent cerebral oedema during diabetic ketoacidosis (DKA) is rare and more common in children and young adults. Subclinical oedema with mild brain dysfunction is more frequent, with unknown long term effects. Rapid tonicity changes may be a factor although not well studied. Guidelines recommend capping hypertonicity resolution at
ISSN:	1441-2772
DOI:	10.1016/S1441-2772(23)00553-7