Supplemental MRI Screening for Women with Extremely Dense Breast Tissue
In this randomized trial, women with extremely dense breast tissue were invited to undergo MRI screening or received only mammography during a 2-year screening period. There was a 50% lower rate of interval cancers among the women invited for MRI screening. Among those who underwent MRI-directed bio...
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| Veröffentlicht in: | The New England journal of medicine 2019-11, Vol.381 (22), p.2091-2102 |
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| container_title | The New England journal of medicine |
| container_volume | 381 |
| creator | Bakker, Marije F de Lange, Stéphanie V Pijnappel, Ruud M Mann, Ritse M Peeters, Petra H.M Monninkhof, Evelyn M Emaus, Marleen J Loo, Claudette E Bisschops, Robertus H.C Lobbes, Marc B.I de Jong, Matthijn D.F Duvivier, Katya M Veltman, Jeroen Karssemeijer, Nico de Koning, Harry J van Diest, Paul J Mali, Willem P.T.M van den Bosch, Maurice A.A.J Veldhuis, Wouter B van Gils, Carla H |
| description | In this randomized trial, women with extremely dense breast tissue were invited to undergo MRI screening or received only mammography during a 2-year screening period. There was a 50% lower rate of interval cancers among the women invited for MRI screening. Among those who underwent MRI-directed biopsies, 26% had breast cancer. |
| doi_str_mv | 10.1056/NEJMoa1903986 |
| format | Article |
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There was a 50% lower rate of interval cancers among the women invited for MRI screening. Among those who underwent MRI-directed biopsies, 26% had breast cancer.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1903986</identifier><identifier>PMID: 31774954</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Aged ; Biopsy ; Breast - diagnostic imaging ; Breast - pathology ; Breast cancer ; Breast Density ; Breast Neoplasms - diagnostic imaging ; Breast Neoplasms - epidemiology ; Early Detection of Cancer - methods ; False Positive Reactions ; Female ; Follow-Up Studies ; Humans ; Magnetic Resonance Imaging ; Mammography ; Medical research ; Middle Aged ; Mortality ; NMR ; Nuclear magnetic resonance ; R&D ; Research & development ; Risk factors ; Sensitivity and Specificity ; Software ; Womens health</subject><ispartof>The New England journal of medicine, 2019-11, Vol.381 (22), p.2091-2102</ispartof><rights>Copyright © 2019 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2019 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-60685fe1bce545c72bfe03389eb023b51a81638a21b420edad755b20d87a79c3</citedby><cites>FETCH-LOGICAL-c390t-60685fe1bce545c72bfe03389eb023b51a81638a21b420edad755b20d87a79c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1903986$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1903986$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31774954$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bakker, Marije F</creatorcontrib><creatorcontrib>de Lange, Stéphanie V</creatorcontrib><creatorcontrib>Pijnappel, Ruud M</creatorcontrib><creatorcontrib>Mann, Ritse M</creatorcontrib><creatorcontrib>Peeters, Petra H.M</creatorcontrib><creatorcontrib>Monninkhof, Evelyn M</creatorcontrib><creatorcontrib>Emaus, Marleen J</creatorcontrib><creatorcontrib>Loo, Claudette E</creatorcontrib><creatorcontrib>Bisschops, Robertus H.C</creatorcontrib><creatorcontrib>Lobbes, Marc B.I</creatorcontrib><creatorcontrib>de Jong, Matthijn D.F</creatorcontrib><creatorcontrib>Duvivier, Katya M</creatorcontrib><creatorcontrib>Veltman, Jeroen</creatorcontrib><creatorcontrib>Karssemeijer, Nico</creatorcontrib><creatorcontrib>de Koning, Harry J</creatorcontrib><creatorcontrib>van Diest, Paul J</creatorcontrib><creatorcontrib>Mali, Willem P.T.M</creatorcontrib><creatorcontrib>van den Bosch, Maurice A.A.J</creatorcontrib><creatorcontrib>Veldhuis, Wouter B</creatorcontrib><creatorcontrib>van Gils, Carla H</creatorcontrib><creatorcontrib>DENSE Trial Study Group</creatorcontrib><title>Supplemental MRI Screening for Women with Extremely Dense Breast Tissue</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this randomized trial, women with extremely dense breast tissue were invited to undergo MRI screening or received only mammography during a 2-year screening period. There was a 50% lower rate of interval cancers among the women invited for MRI screening. Among those who underwent MRI-directed biopsies, 26% had breast cancer.</description><subject>Aged</subject><subject>Biopsy</subject><subject>Breast - diagnostic imaging</subject><subject>Breast - pathology</subject><subject>Breast cancer</subject><subject>Breast Density</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Early Detection of Cancer - methods</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Mammography</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>R&D</subject><subject>Research & development</subject><subject>Risk factors</subject><subject>Sensitivity and Specificity</subject><subject>Software</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp10E1Lw0AQBuBFFFurR6-yIIKX6OxXkj1qrbViFWzBY9gkE03JR91N0P57o62CgnOZwzy8DC8hhwzOGCj__H50O60N0yB06G-RPlNCeFKCv036ADz0ZKBFj-w5t4BumNS7pCdYEEitZJ-MZ-1yWWCJVWMKOn2c0FliEau8eqZZbelT3Z3oW9680NF7YztYrOgVVg7ppUXjGjrPnWtxn-xkpnB4sNkDMr8ezYc33t3DeDK8uPMSoaHxfPBDlSGLE1RSJQGPMwQhQo0xcBErZkLmi9BwFksOmJo0UCrmkIaBCXQiBuR0Hbu09WuLronK3CVYFKbCunURF0wrYFyojh7_oYu6tVX33JfiSjIOnfLWKrG1cxazaGnz0thVxCD6LDj6VXDnjzapbVxi-qO_G-3AyRqUpYsqXJT_BH0AeQJ_rg</recordid><startdate>20191128</startdate><enddate>20191128</enddate><creator>Bakker, Marije F</creator><creator>de Lange, Stéphanie V</creator><creator>Pijnappel, Ruud M</creator><creator>Mann, Ritse M</creator><creator>Peeters, Petra H.M</creator><creator>Monninkhof, Evelyn M</creator><creator>Emaus, Marleen J</creator><creator>Loo, Claudette E</creator><creator>Bisschops, Robertus H.C</creator><creator>Lobbes, Marc B.I</creator><creator>de Jong, Matthijn D.F</creator><creator>Duvivier, Katya M</creator><creator>Veltman, Jeroen</creator><creator>Karssemeijer, Nico</creator><creator>de Koning, Harry J</creator><creator>van Diest, Paul J</creator><creator>Mali, Willem P.T.M</creator><creator>van den Bosch, Maurice A.A.J</creator><creator>Veldhuis, Wouter B</creator><creator>van Gils, Carla H</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20191128</creationdate><title>Supplemental MRI Screening for Women with Extremely Dense Breast Tissue</title><author>Bakker, Marije F ; de Lange, Stéphanie V ; Pijnappel, Ruud M ; Mann, Ritse M ; Peeters, Petra H.M ; Monninkhof, Evelyn M ; Emaus, Marleen J ; Loo, Claudette E ; Bisschops, Robertus H.C ; Lobbes, Marc B.I ; de Jong, Matthijn D.F ; Duvivier, Katya M ; Veltman, Jeroen ; Karssemeijer, Nico ; de Koning, Harry J ; van Diest, Paul J ; Mali, Willem P.T.M ; van den Bosch, Maurice A.A.J ; Veldhuis, Wouter B ; van Gils, Carla H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-60685fe1bce545c72bfe03389eb023b51a81638a21b420edad755b20d87a79c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aged</topic><topic>Biopsy</topic><topic>Breast - 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There was a 50% lower rate of interval cancers among the women invited for MRI screening. Among those who underwent MRI-directed biopsies, 26% had breast cancer.</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>31774954</pmid><doi>10.1056/NEJMoa1903986</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2019-11, Vol.381 (22), p.2091-2102 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine |
| subjects | Aged Biopsy Breast - diagnostic imaging Breast - pathology Breast cancer Breast Density Breast Neoplasms - diagnostic imaging Breast Neoplasms - epidemiology Early Detection of Cancer - methods False Positive Reactions Female Follow-Up Studies Humans Magnetic Resonance Imaging Mammography Medical research Middle Aged Mortality NMR Nuclear magnetic resonance R&D Research & development Risk factors Sensitivity and Specificity Software Womens health |
| title | Supplemental MRI Screening for Women with Extremely Dense Breast Tissue |
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