Afobazole Alleviates Cognitive Rigidity in Experimental Model of Autism Spectrum Disorders

Afobazole (10 mg/kg) alleviated cognitive rigidity in BALB/c mice, a phenotypic model of autism spectrum disorders. It improved spatial memory and retraining in T-maze with drinking reinforcement and restored the retrieval of acquired skill during reversal learning in Morris water maze.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-12, Vol.168 (2), p.238-241
Hauptverfasser:	Kapitsa, I. G., Kalinina, A. P., Alymov, A. A., Voronina, T. A., Seredenin, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Psychological - drug effects Analysis Animals Anti-Anxiety Agents - pharmacology Autism Autism Spectrum Disorder - drug therapy Benzimidazoles - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Cognition - drug effects Disease Models, Animal Internal Medicine Laboratory Medicine Male Maze Learning - drug effects Mice Mice, Inbred BALB C Morpholines - pharmacology Pathology Psychological Distress Spatial Memory - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Afobazole (10 mg/kg) alleviated cognitive rigidity in BALB/c mice, a phenotypic model of autism spectrum disorders. It improved spatial memory and retraining in T-maze with drinking reinforcement and restored the retrieval of acquired skill during reversal learning in Morris water maze.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04682-y