Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding

The interaction of the GAF protein with the promoters of neuron-specific genes during activation and repression of transcription was studied. We showed that, while the Su(Hw) protein remains stably associated with the promoters of these genes at different transcriptional state, the GAF protein level...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2019-09, Vol.488 (1), p.293-295
Hauptverfasser:	Elizar’ev, P. V., Chetverina, D. A., Melnikova, L. S., Srivastava, A., Mishra, R. K., Golovnin, A. K., Georgiev, P. G., Erokhin, M. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Drosophila melanogaster Drosophila Proteins - biosynthesis Drosophila Proteins - genetics Drosophila Proteins - metabolism Gene Expression Regulation Gene silencing Life Sciences Molecular Biology Promoter Regions, Genetic Promoters Proteins Repressor Proteins - genetics Repressor Proteins - metabolism Su(Hw) protein Transcription activation Transcription Factors - biosynthesis Transcription Factors - genetics Transcription, Genetic
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Zusammenfassung:	The interaction of the GAF protein with the promoters of neuron-specific genes during activation and repression of transcription was studied. We showed that, while the Su(Hw) protein remains stably associated with the promoters of these genes at different transcriptional state, the GAF protein level is significantly higher when transcription is activated.
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S1607672919050016