Role of T1 mapping to evaluate brain aging in a healthy population

To investigate the relationship between healthy brain aging and T1 relaxation time obtained by T1 mapping. A total of 211 (102 males, 109 females; age range: 20–89 years; mean age: 54 years) healthy volunteers underwent T1 mapping between July 2018 and January 2019. Regions of interest (ROIs) were placed on T1 maps in different anatomical regions, including the thalamus, putamen, globus pallidus, head of the caudate nucleus, nucleus accumbens, genu of the corpus callosum, and frontal lobe white matter (WM). Additionally, linear and quadratic regression analyses of ROIs were performed. There were significant quadratic and negative linear correlations between T1 relaxation times in the thalamus, putamen, and age (p