The short‐term effects of angiotensin II receptor blockers on albuminuria and renal function in Korean patients

Each angiotensin II receptor blocker (ARB) asserts independent molecular effects. No study has compared the renoprotective potency of different types of ARBs in Korea. This study evaluated the differences among medications for treating albuminuria. Data were obtained from electronic medical records...

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Veröffentlicht in:Basic & clinical pharmacology & toxicology 2020-05, Vol.126 (5), p.424-431
Hauptverfasser: Shin, Juyoung, Kim, Hun‐Sung, Min Kim, Tong, Kim, Hyunah, Lee, Seung‐Hwan, Hyoung Cho, Jae, Lee, Hyunyong, Woo Yim, Hyeon, Yoon, Kun‐Ho
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Sprache:eng
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Zusammenfassung:Each angiotensin II receptor blocker (ARB) asserts independent molecular effects. No study has compared the renoprotective potency of different types of ARBs in Korea. This study evaluated the differences among medications for treating albuminuria. Data were obtained from electronic medical records of adult patients who underwent albuminuria test and received treatment with either angiotensin‐converting enzyme inhibitors (ACEIs) or ARBs between January 2009 and June 2016. Patients' albuminuria and renal function data were observed for three months after treatment initiation. In total, 1475 patients were included. Patients treated with ACEIs had no significant changes in albuminuria (from 127.7 ± 55.1 mg/g to 46.7 ± 18.7 mg/g, P = .127), but those treated with ARBs showed significant improvement (from 491.2 ± 33.2 mg/g to 372.0 ± 28.0 mg/g, P 
ISSN:1742-7835
1742-7843
DOI:10.1111/bcpt.13369