A Niche for Plasma Cells: The Skin

Antibodies are key components of the skin immune barrier, and antibodies directed toward skin structures can result in disease. Wilson et al. (2019) show that healthy skin is a niche for antibody secreting plasma cells and plasmablasts, and that inflammation and immunization increase their numbers....

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Veröffentlicht in:Journal of investigative dermatology 2019-12, Vol.139 (12), p.2411-2414
Hauptverfasser: Karaaslan, Selda, Tomayko, Mary M.
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container_title Journal of investigative dermatology
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creator Karaaslan, Selda
Tomayko, Mary M.
description Antibodies are key components of the skin immune barrier, and antibodies directed toward skin structures can result in disease. Wilson et al. (2019) show that healthy skin is a niche for antibody secreting plasma cells and plasmablasts, and that inflammation and immunization increase their numbers. This work advances our understanding of skin associated B and plasma cells in health and disease.
doi_str_mv 10.1016/j.jid.2019.06.133
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source MEDLINE; Free E-Journal (出版社公開部分のみ); Alma/SFX Local Collection
subjects Humans
Immunization
Immunoglobulin M
Inflammation
Plasma Cells
Skin
title A Niche for Plasma Cells: The Skin
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