A Niche for Plasma Cells: The Skin

A Niche for Plasma Cells: The Skin

Antibodies are key components of the skin immune barrier, and antibodies directed toward skin structures can result in disease. Wilson et al. (2019) show that healthy skin is a niche for antibody secreting plasma cells and plasmablasts, and that inflammation and immunization increase their numbers....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of investigative dermatology 2019-12, Vol.139 (12), p.2411-2414
Hauptverfasser: Karaaslan, Selda, Tomayko, Mary M.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Immunization
Immunoglobulin M
Inflammation
Plasma Cells
Skin
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Antibodies are key components of the skin immune barrier, and antibodies directed toward skin structures can result in disease. Wilson et al. (2019) show that healthy skin is a niche for antibody secreting plasma cells and plasmablasts, and that inflammation and immunization increase their numbers. This work advances our understanding of skin associated B and plasma cells in health and disease.
ISSN:0022-202X
1523-1747
DOI:10.1016/j.jid.2019.06.133