Effects of valproic acid on bone mineral density and bone metabolism: A meta-analysis

•Many patients with epilepsy need medication long time.•Risk of fracture was increased by long-term antiepileptic drugs.•Valproic acid may reduce bone mineral density and affect bone metabolism of patients. Numerous studies have shown that the risk of fracture is increased by long-term antiepileptic...

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Veröffentlicht in:	Seizure (London, England) England), 2019-12, Vol.73, p.56-63
Hauptverfasser:	Fan, Danyang, Miao, Jie, Fan, Xiuqin, Wang, Qiong, Sun, Meizhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - adverse effects Bone and Bones - drug effects Bone and Bones - metabolism Bone Density - drug effects Bone metabolism Bone mineral density Epilepsy Epilepsy - drug therapy Humans Meta-analysis Valproic acid Valproic Acid - adverse effects
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