Effects of valproic acid on bone mineral density and bone metabolism: A meta-analysis

•Many patients with epilepsy need medication long time.•Risk of fracture was increased by long-term antiepileptic drugs.•Valproic acid may reduce bone mineral density and affect bone metabolism of patients. Numerous studies have shown that the risk of fracture is increased by long-term antiepileptic...

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Veröffentlicht in:	Seizure (London, England) England), 2019-12, Vol.73, p.56-63
Hauptverfasser:	Fan, Danyang, Miao, Jie, Fan, Xiuqin, Wang, Qiong, Sun, Meizhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - adverse effects Bone and Bones - drug effects Bone and Bones - metabolism Bone Density - drug effects Bone metabolism Bone mineral density Epilepsy Epilepsy - drug therapy Humans Meta-analysis Valproic acid Valproic Acid - adverse effects
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Zusammenfassung:	•Many patients with epilepsy need medication long time.•Risk of fracture was increased by long-term antiepileptic drugs.•Valproic acid may reduce bone mineral density and affect bone metabolism of patients. Numerous studies have shown that the risk of fracture is increased by long-term antiepileptic drugs (AEDs). Valproic acid (VPA) is one of the most commonly used AEDs. In this meta-analysis, we aimed to assess the effects of VPA on bone mineral density (BMD) and bone metabolism. PubMed, Embase, Cochrane and Web of Science databases were searched from inception to January 2019 for articles focusing on the effects of VPA on BMD and bone metabolism in adults or children. A meta-analysis was performed using RevMan 5. 3 software. 18 studies were included in the meta-analysis. The BMD of lumber spine (MD= −0.06, 95%CI: −0.09 to −0.03, P
ISSN:	1059-1311 1532-2688
DOI:	10.1016/j.seizure.2019.10.017