Docking Complete: A Step Further toward the Holy Grail of γδ T Cell Biology

The direct ligands recognized by γδ T cell receptors (γδ TCRs) remain uncertain and controversial. In a study appearing in this issue, Willcox et al. use surface plasmon resonance and isothermal titration calorimetry to demonstrate that B7-like molecule BTNL3 makes physical contact with V4γ-bearing...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2019-11, Vol.51 (5), p.781-783
Hauptverfasser:	Cai, Ningning, Han, Shuai, Zhang, Yonghui
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens B7 antigen Biology Butyrophilins Calorimetry Cell Membrane Humans Ligands Lymphocytes Lymphocytes T Microscopy Mutagenesis Mutation Proteins Receptors Receptors, Antigen, T-Cell, gamma-delta Studies Surface plasmon resonance T cell receptors T-Lymphocytes Titration Titration calorimetry
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Beschreibung
Zusammenfassung:	The direct ligands recognized by γδ T cell receptors (γδ TCRs) remain uncertain and controversial. In a study appearing in this issue, Willcox et al. use surface plasmon resonance and isothermal titration calorimetry to demonstrate that B7-like molecule BTNL3 makes physical contact with V4γ-bearing TCRs on γδ T cells. The direct ligands recognized by γδ T cell receptors (γδ TCRs) remain uncertain and controversial. In a study appearing in this issue, Willcox et al. use surface plasmon resonance and isothermal titration calorimetry to demonstrate that B7-like molecule BTNL3 makes physical contact with V4γ-bearing TCRs on γδ T cells.
ISSN:	1074-7613 1097-4180
DOI:	10.1016/j.immuni.2019.10.013