Patterns of failure and outcomes in cT4 Oral squamous cell carcinoma (OSCC) undergoing upfront surgery in comparison to Neo-Adjuvant Chemotherapy (NACT) followed by surgery: A Matched Pair analysis

Patterns of failure and outcomes in cT4 Oral squamous cell carcinoma (OSCC) undergoing upfront surgery in comparison to Neo-Adjuvant Chemotherapy (NACT) followed by surgery: A Matched Pair analysis

•The role of NACT in T4 oral cancers remains a contentious issue with sparse evidence in literature.•cT4b oral cancers performed better when they received NACT prior to surgery in comparision to cT4a oral cancers.•Results of our matched pair analysis are hypothesis generating which needs to be teste...

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Veröffentlicht in:Oral oncology 2020-01, Vol.100, p.104455-104455, Article 104455
Hauptverfasser: Thiagarajan, Shivakumar, Dhar, Harsh, Bhattacharjee, Atanu, Fatehi, Khuzema Saifuddin, Shah, Snehal Bhupesh, Chaukar, Devendra, Nair, Deepa, Deshmukh, Anuja, Prabhash, Kumar, Joshi, Amit, Patil, Vijay, Noronha, Vanita, Laskar, Sarbani Ghosh, Cruz, Anil K.D.
Format: Artikel
Sprache:eng
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Zusammenfassung:•The role of NACT in T4 oral cancers remains a contentious issue with sparse evidence in literature.•cT4b oral cancers performed better when they received NACT prior to surgery in comparision to cT4a oral cancers.•Results of our matched pair analysis are hypothesis generating which needs to be tested in a randomized trial.
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2019.104455