Intraoperative Ultrasound Guidance With an Ultrasound‐Visible Clip: A Practical and Cost‐effective Option for Breast Cancer Localization

Objectives In partial mastectomy (PM) or lumpectomy, ultrasound (US) localization avoids discomfort and additional procedures associated with wire localization. The purpose of this study was to evaluate the association between ultrasound‐visible clip (UVC) use at the time of biopsy and US use during resection, hypothesizing that UVCs facilitate US localization and reduce costs compared with traditional radiopaque clips or no clip placement. Methods The study population consisted of adult female patients with breast cancer undergoing PM or lumpectomy at our institution between 2014 and 2016. The core biopsy clip type and localization method during PM were characterized as wire localization versus US localization, and associations were estimated with multivariable regression models. For the cost evaluation, breast biopsy data were obtained from the Department of Radiology. Results Among 674 patients, 490 had data on localization and the clip type. Ultrasound‐visible clip placement at biopsy increased US use during resection by 13% (95% confidence interval, 6%–21%). There was no difference in the total specimen weight with US versus wire localization. The cost savings for using UVCs for the 2209 patients who underwent breast biopsy from 2014 to 2016 was $36,000. Conclusions This study demonstrates that US localization for PM is feasible at a single institution and cost‐effective when facilitated by UVCs. Placement of a UVC at the time of biopsy is recommended, as it is cost‐effective and avoids the discomfort and inconvenience of wire localization.