Evaluation of intestinal permeation enhancement with carboxymethyl chitosan-rhein polymeric micelles for oral delivery of paclitaxel

[Display omitted] Polymeric micelles (PMs) are currently under investigation as potential nanocarriers for oral administration of paclitaxel (PTX). Previously, we developed amphiphilic carboxymethyl chitosan-rhein (CR) conjugate for oral delivery of PTX. PTX-loaded CR PMs exhibited a homogeneous and...

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Veröffentlicht in:	International journal of pharmaceutics 2020-01, Vol.573, p.118840-118840, Article 118840
Hauptverfasser:	Wang, Xiaoying, Qiu, Liangzhen, Wang, Xiaying, Ouyang, Huizhi, Li, Tonglei, Han, Lifeng, Zhang, Xue, Xu, Wei, Chu, Kedan
Format:	Artikel
Sprache:	eng
Schlagworte:	Carboxymethyl chitosan-rhein conjugate Intestinal permeation enhancement Paclitaxel Polymeric micelles
Online-Zugang:	Volltext
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Zusammenfassung:	[Display omitted] Polymeric micelles (PMs) are currently under investigation as potential nanocarriers for oral administration of paclitaxel (PTX). Previously, we developed amphiphilic carboxymethyl chitosan-rhein (CR) conjugate for oral delivery of PTX. PTX-loaded CR PMs exhibited a homogeneous and small size (
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2019.118840