Direct Access to Allenylphosphine Oxides via a Metal Free Coupling of Propargylic Substrates with P(O)H Compounds

Direct Access to Allenylphosphine Oxides via a Metal Free Coupling of Propargylic Substrates with P(O)H Compounds

A direct and convenient approach for the coupling of propargylic substrates with diphenylphosphine oxide in the presence of Tf2O and 2,6-lutidine has been developed. The method provides a general approach for the construction of attractive allenylphosphoryl skeletons with high atom and step economy...

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Veröffentlicht in:Organic letters 2019-12, Vol.21 (23), p.9438-9441
Hauptverfasser: Yang, Chun-Hua, Fan, Huihui, Li, Huimin, Hou, Shenyin, Sun, Xiangkun, Luo, Donghao, Zhang, Yinchao, Yang, Zhantao, Chang, Junbiao
Format: Artikel
Sprache:eng
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Zusammenfassung:A direct and convenient approach for the coupling of propargylic substrates with diphenylphosphine oxide in the presence of Tf2O and 2,6-lutidine has been developed. The method provides a general approach for the construction of attractive allenylphosphoryl skeletons with high atom and step economy under metal free conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03645