Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia
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| Veröffentlicht in: | Leukemia 2019-11, Vol.33 (11), p.2732-2766 |
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| container_title | Leukemia |
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| creator | Hosokawa, Kohei Mizumaki, Hiroki Elbadry, Mahmoud I. Saito, Chizuru Espinoza, J. Luis Thi Thanh Dao, An Katagiri, Takamasa Harashima, Ai Kikuchi, Akihiro Kanai, Akinori Matsui, Hirotaka Inaba, Toshiya Taniwaki, Masafumi Yamamoto, Yasuhiko Nakao, Shinji |
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| doi_str_mv | 10.1038/s41375-019-0510-0 |
| format | Article |
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Luis ; Thi Thanh Dao, An ; Katagiri, Takamasa ; Harashima, Ai ; Kikuchi, Akihiro ; Kanai, Akinori ; Matsui, Hirotaka ; Inaba, Toshiya ; Taniwaki, Masafumi ; Yamamoto, Yasuhiko ; Nakao, Shinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-97418aa6ff238260f54da8177ae7a415dbfc585be9a921bd78960045d8b9949a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>38/23</topic><topic>42/89</topic><topic>631/532/1542</topic><topic>631/80/86</topic><topic>82/1</topic><topic>82/51</topic><topic>82/83</topic><topic>96/95</topic><topic>Anemia</topic><topic>Anemia, Aplastic - genetics</topic><topic>Anemia, Aplastic - metabolism</topic><topic>Aplastic anemia</topic><topic>Autocrine signalling</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Cancer Research</topic><topic>Cell Proliferation</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 13</topic><topic>Critical Care Medicine</topic><topic>Cytokines - metabolism</topic><topic>Exome</topic><topic>Genetic research</topic><topic>Hematology</topic><topic>Hematopoiesis</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Humans</topic><topic>Immune system</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Inflammation</topic><topic>Intensive</topic><topic>Internal Medicine</topic><topic>K562 Cells</topic><topic>Letter</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutation</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Oncology</topic><topic>Phenotype</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Remission Induction</topic><topic>Roundabout Proteins</topic><topic>STAT3 Transcription Factor - metabolism</topic><topic>Stem cells</topic><topic>Stem Cells - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosokawa, Kohei</creatorcontrib><creatorcontrib>Mizumaki, Hiroki</creatorcontrib><creatorcontrib>Elbadry, Mahmoud I.</creatorcontrib><creatorcontrib>Saito, Chizuru</creatorcontrib><creatorcontrib>Espinoza, J. 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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | 38/23 42/89 631/532/1542 631/80/86 82/1 82/51 82/83 96/95 Anemia Anemia, Aplastic - genetics Anemia, Aplastic - metabolism Aplastic anemia Autocrine signalling Bone Marrow Cells - metabolism Cancer Research Cell Proliferation Chromosome Aberrations Chromosomes, Human, Pair 13 Critical Care Medicine Cytokines - metabolism Exome Genetic research Hematology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - cytology Humans Immune system In Situ Hybridization, Fluorescence Inflammation Intensive Internal Medicine K562 Cells Letter Medicine Medicine & Public Health Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oncology Phenotype Receptors, Immunologic - metabolism Remission Induction Roundabout Proteins STAT3 Transcription Factor - metabolism Stem cells Stem Cells - cytology |
| title | Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia |
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