Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia

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Veröffentlicht in:	Leukemia 2019-11, Vol.33 (11), p.2732-2766
Hauptverfasser:	Hosokawa, Kohei, Mizumaki, Hiroki, Elbadry, Mahmoud I., Saito, Chizuru, Espinoza, J. Luis, Thi Thanh Dao, An, Katagiri, Takamasa, Harashima, Ai, Kikuchi, Akihiro, Kanai, Akinori, Matsui, Hirotaka, Inaba, Toshiya, Taniwaki, Masafumi, Yamamoto, Yasuhiko, Nakao, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	38/23 42/89 631/532/1542 631/80/86 82/1 82/51 82/83 96/95 Anemia Anemia, Aplastic - genetics Anemia, Aplastic - metabolism Aplastic anemia Autocrine signalling Bone Marrow Cells - metabolism Cancer Research Cell Proliferation Chromosome Aberrations Chromosomes, Human, Pair 13 Critical Care Medicine Cytokines - metabolism Exome Genetic research Hematology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - cytology Humans Immune system In Situ Hybridization, Fluorescence Inflammation Intensive Internal Medicine K562 Cells Letter Medicine Medicine & Public Health Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oncology Phenotype Receptors, Immunologic - metabolism Remission Induction Roundabout Proteins STAT3 Transcription Factor - metabolism Stem cells Stem Cells - cytology
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