Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

Insulin resistance is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, and nonalcoholic liver disease. A recent study of mouse models implicates elevated levels of ceramide and their effect on mitochondrial function in the mediation of cellular insulin...

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Veröffentlicht in:The New England journal of medicine 2019-11, Vol.381 (19), p.1866-1869
Hauptverfasser: Samuel, Varman T, Shulman, Gerald I
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Arteriosclerosis
Ceramide
Diabetes mellitus (non-insulin dependent)
Disease resistance
Fatty liver
Glucose
Insulin
Insulin resistance
Kinases
Lipids
Liver diseases
Mitochondria
Obesity
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container_end_page 1869
container_issue 19
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container_title The New England journal of medicine
container_volume 381
creator Samuel, Varman T
Shulman, Gerald I
description Insulin resistance is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, and nonalcoholic liver disease. A recent study of mouse models implicates elevated levels of ceramide and their effect on mitochondrial function in the mediation of cellular insulin resistance.
doi_str_mv 10.1056/NEJMcibr1910023
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source New England Journal of Medicine Current; EZB Electronic Journals Library
subjects Animal models
Arteriosclerosis
Ceramide
Diabetes mellitus (non-insulin dependent)
Disease resistance
Fatty liver
Glucose
Insulin
Insulin resistance
Kinases
Lipids
Liver diseases
Mitochondria
Obesity
title Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides
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