Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

Insulin resistance is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, and nonalcoholic liver disease. A recent study of mouse models implicates elevated levels of ceramide and their effect on mitochondrial function in the mediation of cellular insulin...

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Veröffentlicht in:	The New England journal of medicine 2019-11, Vol.381 (19), p.1866-1869
Hauptverfasser:	Samuel, Varman T, Shulman, Gerald I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Arteriosclerosis Ceramide Diabetes mellitus (non-insulin dependent) Disease resistance Fatty liver Glucose Insulin Insulin resistance Kinases Lipids Liver diseases Mitochondria Obesity
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Insulin resistance is a precursor to and accelerant of coexisting conditions such as type 2 diabetes, atherosclerosis, and nonalcoholic liver disease. A recent study of mouse models implicates elevated levels of ceramide and their effect on mitochondrial function in the mediation of cellular insulin resistance.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMcibr1910023