Hematological toxicities associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Hematological toxicities associated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Introduction Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in selected patients with peritoneal disease, but the extent of cytoreduction and chemoperfusion can result in systemic toxicities. We evaluate the incidence of perioper...

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Veröffentlicht in:Asia-Pacific journal of clinical oncology 2020-04, Vol.16 (2), p.e38-e46
Hauptverfasser: Wong, Evelyn Y. T., Tan, Grace H. C., Kumar, Mrinal, Teo, Melissa C. C.
Format: Artikel
Sprache:eng
Schlagworte:
Chemotherapy
hematological
Hematology
HIPEC
Leukocytes (neutrophilic)
Leukopenia
Mesothelioma
Metastases
Neutropenia
Peritoneal diseases
peritoneal metastases
Peritoneum
Risk factors
Surgery
Thrombocytopenia
toxicities
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Zusammenfassung:Introduction Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been found to prolong survival in selected patients with peritoneal disease, but the extent of cytoreduction and chemoperfusion can result in systemic toxicities. We evaluate the incidence of perioperative hematological complications and its associated risk factors. Methods Retrospective analysis of a prospectively collected database of CRS‐HIPEC cases between April 2001 and October 2016 was performed. Patients were stratified based on the clinicopathological characteristics, perioperative incidence, grade, and duration of leukopenia (white blood cells 
ISSN:1743-7555
1743-7563
DOI:10.1111/ajco.13275