Targeting miRNAs by polyphenols: Novel therapeutic strategy for aging

[Display omitted] Regarding the importance of genetic and epigenetic factors in regulation of aging process, different expression pattern of non-coding RNAs in aging could be investigated. Accordingly, micro RNAs (miRNAs) with a wide range of physiological functions as well as a significant footprint in many diseases have been demonstrated to be down or upregulated during the aging process. Therefore, age‐associated microRNAs and their targets have potentially detected the accelerated aging and predicted the risks for age‐related diseases. Polyphenols as important antioxidants in human dietary observed in fruits and some beverages have beneficial effects on longevity and aging. Considering miRNAs as an interesting mediator in modulating polyphenols′ biological effects, targeting miRNAs which is using polyphenols could be a novel strategy for aging.