Serum angiopoietin‐2 level as a novel biomarker in atopic dermatitis

Background Atopic dermatitis (AD) is a chronic, pruritic inflammatory skin disease. Angiopoietin is an intrinsic mediator induced by T helper 2 cytokines and has been reported it to play a critical role in the pathogenesis of AD. Objectives To determine the relationship between circulating angiopoietin‐2 (Ang‐2) in AD patients and to determine its correlation with the severity and chronicity of the disease. Methods The present study included 38 AD patients and 38 healthy controls, age‐ and sex‐matched. We collected 3 mm of venous blood from each subject. Enzyme‐linked immunosorbent assay (ELISA) determined serum angiopoietin. We determined the correlation between serum Ang‐2 level, duration of disease, severity, type of atopy, and scoring atopic dermatitis (SCORAD) score. Results There were highly significant differences between patients and controls with regard to serum Ang‐2 levels (P