Outstanding questions in transplantation: Tolerance

In 2017, the American Society of Transplantation (AST) launched the Outstanding Questions in Transplantation Research forum to stimulate a community‐wide discussion of how the field is evolving and to help identify areas where a better dialogue between clinicians and researchers could result in great advancements. Tolerance emerged as a topic of great interest to the AST community. This minireview provides an overview of clinical transplantation tolerance. Historical background followed by a review of the current status of attempts to establish tolerance in the clinic, highlighting the dynamic online discussion surrounding this important topic from the AST Transplantation Research forum, is provided. This minireview provides an overview of the current state of clinical transplantation tolerance, highlighting discussions on the topic by the "Outstanding Questions in Transplantation Research" forum organized by the American Society of Transplantation.