Niche origin of mesenchymal stem cells derived microvesicles determines opposing effects on NSCLC: Primary versus metastatic

•Mesenchymal stem cells' (MSCs) microvesicles (MVs) alter NSCLC cells' phenotype.•Lung-MSCs' MVs promoted.•BM-MSCs' MVs suppressed NSCLC cells' cancerous phenotype.•The systemic nature of MVs marks them as attractive therapeutic markers/targets. Novel therapeutic approaches...

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Veröffentlicht in:	Cellular signalling 2020-01, Vol.65, p.109456-109456, Article 109456
Hauptverfasser:	Attar-Schneider, Oshrat, Dabbah, Mahmoud, Drucker, Liat, Gottfried, Maya
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Autophagy - drug effects Biomarkers, Tumor - metabolism Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Movement Cell Proliferation - genetics Cell Survival - drug effects Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology Cell-Derived Microparticles - physiology Cell-Derived Microparticles - ultrastructure Eukaryotic Initiation Factor-4E - metabolism Eukaryotic Initiation Factor-4G - metabolism Female Humans Lung - cytology Lung - metabolism Lung - pathology Lung Neoplasms - metabolism Lung Neoplasms - pathology Male MAP Kinase Signaling System - genetics Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Microscopy, Electron, Transmission Microvesicles Middle Aged Migration NSCLC Peptide Chain Initiation, Translational - genetics Tumor Microenvironment
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