Monte Carlo investigation of electron specific energy distribution in a single cell model
Knowledge of microdosimetric quantities of certain radionuclides is important in radio immune cancer therapies. Specific energy distribution of radionuclides, which are bound to the cell, is the microdosimetric quantity essential in the process of radionuclide selection for patient tumour treatment....
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| Veröffentlicht in: | Radiation and environmental biophysics 2020-03, Vol.59 (1), p.161-171 |
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| creator | Markovic, V. M. Stevanovic, N. Nikezic, D. |
| description | Knowledge of microdosimetric quantities of certain radionuclides is important in radio immune cancer therapies. Specific energy distribution of radionuclides, which are bound to the cell, is the microdosimetric quantity essential in the process of radionuclide selection for patient tumour treatment. The aim of this paper is to establish an applicable method to determine microdosimetric quantities for various radionuclides. The established method is based on knowledge of microdosimetric quantities of monoenergetic electrons. In this paper these quantities are determined for the single-cell model for a range of electron energies up to
2.3
MeV
, using the Monte Carlo transport code PENELOPE. The results show that using monoenergetic specific energies, reconstruction of the specific energy of beta-emitting radionuclides can be successfully done with very high accuracy. Microdosimetric quantities share information about the physical processes involved and give insight about energy depositions, which is of use in the procedure of radionuclide selection for a given type of therapy. |
| doi_str_mv | 10.1007/s00411-019-00815-z |
| format | Article |
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2.3
MeV
, using the Monte Carlo transport code PENELOPE. The results show that using monoenergetic specific energies, reconstruction of the specific energy of beta-emitting radionuclides can be successfully done with very high accuracy. Microdosimetric quantities share information about the physical processes involved and give insight about energy depositions, which is of use in the procedure of radionuclide selection for a given type of therapy.</description><identifier>ISSN: 0301-634X</identifier><identifier>EISSN: 1432-2099</identifier><identifier>DOI: 10.1007/s00411-019-00815-z</identifier><identifier>PMID: 31659434</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Beta Particles ; Biological and Medical Physics ; Biophysics ; Computer simulation ; Ecosystems ; Effects of Radiation/Radiation Protection ; Electrons ; Energy ; Energy distribution ; Environmental Physics ; Information processing ; Monitoring/Environmental Analysis ; Monte Carlo Method ; Original Article ; Physics ; Physics and Astronomy ; Radioisotopes ; Radiometry ; Single-Cell Analysis ; Specific energy ; Tumors</subject><ispartof>Radiation and environmental biophysics, 2020-03, Vol.59 (1), p.161-171</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Radiation and Environmental Biophysics is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-812c0bd4fe9856e51feeba3995e563c51facc119101478102c73254619bd9f83</citedby><cites>FETCH-LOGICAL-c375t-812c0bd4fe9856e51feeba3995e563c51facc119101478102c73254619bd9f83</cites><orcidid>0000-0002-5566-8169</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00411-019-00815-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00411-019-00815-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31659434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markovic, V. M.</creatorcontrib><creatorcontrib>Stevanovic, N.</creatorcontrib><creatorcontrib>Nikezic, D.</creatorcontrib><title>Monte Carlo investigation of electron specific energy distribution in a single cell model</title><title>Radiation and environmental biophysics</title><addtitle>Radiat Environ Biophys</addtitle><addtitle>Radiat Environ Biophys</addtitle><description>Knowledge of microdosimetric quantities of certain radionuclides is important in radio immune cancer therapies. Specific energy distribution of radionuclides, which are bound to the cell, is the microdosimetric quantity essential in the process of radionuclide selection for patient tumour treatment. The aim of this paper is to establish an applicable method to determine microdosimetric quantities for various radionuclides. The established method is based on knowledge of microdosimetric quantities of monoenergetic electrons. In this paper these quantities are determined for the single-cell model for a range of electron energies up to
2.3
MeV
, using the Monte Carlo transport code PENELOPE. The results show that using monoenergetic specific energies, reconstruction of the specific energy of beta-emitting radionuclides can be successfully done with very high accuracy. 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M.</au><au>Stevanovic, N.</au><au>Nikezic, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monte Carlo investigation of electron specific energy distribution in a single cell model</atitle><jtitle>Radiation and environmental biophysics</jtitle><stitle>Radiat Environ Biophys</stitle><addtitle>Radiat Environ Biophys</addtitle><date>2020-03-01</date><risdate>2020</risdate><volume>59</volume><issue>1</issue><spage>161</spage><epage>171</epage><pages>161-171</pages><issn>0301-634X</issn><eissn>1432-2099</eissn><abstract>Knowledge of microdosimetric quantities of certain radionuclides is important in radio immune cancer therapies. Specific energy distribution of radionuclides, which are bound to the cell, is the microdosimetric quantity essential in the process of radionuclide selection for patient tumour treatment. The aim of this paper is to establish an applicable method to determine microdosimetric quantities for various radionuclides. 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2.3
MeV
, using the Monte Carlo transport code PENELOPE. The results show that using monoenergetic specific energies, reconstruction of the specific energy of beta-emitting radionuclides can be successfully done with very high accuracy. Microdosimetric quantities share information about the physical processes involved and give insight about energy depositions, which is of use in the procedure of radionuclide selection for a given type of therapy.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31659434</pmid><doi>10.1007/s00411-019-00815-z</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5566-8169</orcidid></addata></record> |
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| subjects | Beta Particles Biological and Medical Physics Biophysics Computer simulation Ecosystems Effects of Radiation/Radiation Protection Electrons Energy Energy distribution Environmental Physics Information processing Monitoring/Environmental Analysis Monte Carlo Method Original Article Physics Physics and Astronomy Radioisotopes Radiometry Single-Cell Analysis Specific energy Tumors |
| title | Monte Carlo investigation of electron specific energy distribution in a single cell model |
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