Genetic Obesity and Bariatric Surgery Outcome in 1014 Patients with Morbid Obesity

Background Mutations in the leptin-melanocortin pathway genes are known to cause monogenic obesity. The prevalence of these gene mutations and their effect on weight loss response after bariatric surgery are still largely unknown. Objective To determine the prevalence of genetic obesity in a large bariatric cohort and evaluate their response to bariatric surgery. Methods Mutation analysis of 52 obesity-associated genes. Patient inclusion criteria were a BMI > 50 kg/m 2 , an indication for revisional surgery or an early onset of obesity (