Outcomes of patients with stroke treated with thrombolysis according to prestroke Rankin Scale scores

Outcomes of patients with stroke treated with thrombolysis according to prestroke Rankin Scale scores

BACKGROUNDIt is common practice to withhold IV thrombolysis (IVT) for acute ischemic stroke in patients with preexisting disabilities. To test the hypothesis of an association of IVT and good clinical outcome also in patients with preexisting disabilities without an increase in mortality, we analyze...

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Veröffentlicht in:Neurology 2019-11, Vol.93 (20), p.e1834-e1843
Hauptverfasser: Gumbinger, Christoph, Ringleb, Peter, Ippen, Franziska, Ungerer, Matthias, Reuter, Björn, Bruder, Ingo, Daffertshofer, Michael, Stock, Christian
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Disabled Persons
Female
Hospital Mortality
Humans
Male
Middle Aged
Retrospective Studies
Severity of Illness Index
Stroke - drug therapy
Stroke - physiopathology
Thrombolytic Therapy - methods
Treatment Outcome
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Zusammenfassung:BACKGROUNDIt is common practice to withhold IV thrombolysis (IVT) for acute ischemic stroke in patients with preexisting disabilities. To test the hypothesis of an association of IVT and good clinical outcome also in patients with preexisting disabilities without an increase in mortality, we analyzed data from 52,741 patients (15,317 treated with IVT) depending on prestroke Rankin Scale (pRS) score. METHODSWe performed an observational study based on a consecutive stroke registry covering 10.8 million inhabitants. The outcome at discharge of patients with stroke admitted in the time window of potential eligibility for IVT (
ISSN:0028-3878
1526-632X
DOI:10.1212/WNL.0000000000008468