Visible Light Photoredox-Catalyzed α‑Alkylation of Cyclic Tertiary Arylamines

Visible Light Photoredox-Catalyzed α‑Alkylation of Cyclic Tertiary Arylamines

An efficient method was successfully developed to obtain cyclic β-amino ketones via visible-light photoredox catalysis. With this catalytic system, vinyl azides and N-Ph pyrrolidines react to form cyclic β-amino ketones by α-amino radical addition. This method provides a simple, mild, straightforwar...

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Veröffentlicht in:Journal of organic chemistry 2019-11, Vol.84 (22), p.14760-14769
Hauptverfasser: Xu, Ji-Tao, Xu, Guo-Qiang, Wang, Zhu-Yin, Xu, Peng-Fei
Format: Artikel
Sprache:eng
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Zusammenfassung:An efficient method was successfully developed to obtain cyclic β-amino ketones via visible-light photoredox catalysis. With this catalytic system, vinyl azides and N-Ph pyrrolidines react to form cyclic β-amino ketones by α-amino radical addition. This method provides a simple, mild, straightforward, and novel paradigm to prepare important β-amino ketones.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.9b02347