Catalytic Asymmetric Aza-Friedel–Crafts-Type Reaction of Indoles with Isatin-Derived N‑Cbz-Ketimines Using a Chiral Bis(Imidazolidine)-Containing NCN-Pincer Palladium Catalyst

Catalytic Asymmetric Aza-Friedel–Crafts-Type Reaction of Indoles with Isatin-Derived N‑Cbz-Ketimines Using a Chiral Bis(Imidazolidine)-Containing NCN-Pincer Palladium Catalyst

A chiral bis­(imidazolidine)-containing NCN-pincer palladium complex (tBu-PhBidine-Pd-OTf) was an efficient catalyst for the aza-Friedel–Crafts-type reaction of 1H-indoles with isatin-derived N-Cbz-ketimines to give chiral 3-aminobisindole compounds having differently oxidized indole units with high...

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Veröffentlicht in:Organic letters 2019-11, Vol.21 (21), p.8572-8576
Hauptverfasser: Arai, Takayoshi, Araseki, Kensuke, Kakino, Junki
Format: Artikel
Sprache:eng
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Zusammenfassung:A chiral bis­(imidazolidine)-containing NCN-pincer palladium complex (tBu-PhBidine-Pd-OTf) was an efficient catalyst for the aza-Friedel–Crafts-type reaction of 1H-indoles with isatin-derived N-Cbz-ketimines to give chiral 3-aminobisindole compounds having differently oxidized indole units with high enantioselectivities.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.9b03148