Cardiovascular responses to a glucose drink in young male individuals with overweight/obesity and mild alterations in glucose metabolism, but without impaired glucose tolerance

Purpose Little is known about whether mild aberrations in glucose metabolism, which are seen in overweight/obese subjects (OW/OB) without impaired glucose tolerance, affect regulator control elements for blood pressure homeostasis. Methods Hence, we measured in age-matched male subjects with normal weight ( n = 16; BMI = 22.4 kg m −2 ) and OW/OB ( n = 11; BMI = 28.6 kg m −2 ) continuous beat-to-beat blood pressure, heart rate, stroke volume, myocardial contractility and baroreflex sensitivity during a 30 min baseline and for 120 min after the ingestion of 75 g glucose dissolved in 300 mL tap water (OGTT). Blood samples for the assessment of plasma glucose and insulin were collected at baseline and every 30 min after the drink and homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Results At baseline, glucose (5.3 ± 0.4 SD vs 5.0 ± 0.4 mmol L −1 ; p = 0.01), insulin (7.4 ± 0.4 vs 3.7 ± 2.7 mU L −1 ; p = 0.02) and HOMA-IR (1.8 ± 1.3 vs 0.8 ± 0.6; p = 0.01) were significantly higher in subjects with OW/OB, but none classified as having impaired glucose tolerance (plasma glucose levels