Sepsis induced cardiomyopathy: Pathophysiology and use of mechanical circulatory support for refractory shock

Sepsis remains a major cause of morbidity and mortality, and sepsis-induced cardiomyopathy (SCM) has been recognized as a relevant complication. In this article, the pathophysiology of SCM and the literature regarding the clinical care with a focus on the use of mechanical circulatory support for the rescue of patients with severe SCM are reviewed. Lastly, a pragmatic approach to the care of this complex patient population is provided using a representative case example. •Sepsis can induce stress cardiomyopathy (takotsubo) and sepsis-induced cardiomyopathy resulting in cardiogenic shock•The article reviews these two acute cardiomyopathies and the role of mechanical circulatory support in these patients.•An algorithm to the care of patients with septic shock and worsening end-organ perfusion is provided.