Computational Approaches to Anesthetic Drug Discovery

Computational Approaches to Anesthetic Drug Discovery

All currently available general anesthetics produce potentially deadly side effects. Unfortunately, few approaches have been developed to design safer ones, despite important advances in anesthetic mechanisms research. Cayla and colleagues recently showed that computational methods can be used to id...

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Veröffentlicht in:Trends in pharmacological sciences (Regular ed.) 2019-11, Vol.40 (11), p.809-811
Hauptverfasser: McGrath, Megan, Pence, Andrea, Raines, Douglas E.
Format: Artikel
Sprache:eng
Schlagworte:
anesthesia
Anesthetics
Drug Discovery
Etomidate
steroids
TG41
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Zusammenfassung:All currently available general anesthetics produce potentially deadly side effects. Unfortunately, few approaches have been developed to design safer ones, despite important advances in anesthetic mechanisms research. Cayla and colleagues recently showed that computational methods can be used to identify anesthetic lead compounds devoid of specific side effects.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2019.09.001