20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia

Familial hypercholesterolemia is marked by very elevated low-density lipoprotein cholesterol levels and premature cardiovascular disease. This 20-year follow-up study showed that statin initiation during childhood in affected persons slowed the progression of carotid intima–media thickness and reduc...

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Veröffentlicht in:	The New England journal of medicine 2019-10, Vol.381 (16), p.1547-1556
Hauptverfasser:	Luirink, Ilse K, Wiegman, Albert, Kusters, D. Meeike, Hof, Michel H, Groothoff, Jaap W, de Groot, Eric, Kastelein, John J.P, Hutten, Barbara A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Age Apolipoproteins Atherosclerosis Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - mortality Cardiovascular Diseases - prevention & control Carotid Intima-Media Thickness Child Children Cholesterol Cholesterol, LDL - blood Disease Progression Family medical history Female Follow-Up Studies Health risk assessment Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypercholesterolemia Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - drug therapy Incidence Lipids Low density lipoprotein Male Mutation Pravastatin Progression-Free Survival Questionnaires Risk Siblings Statins Surveys and Questionnaires Young Adult
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Beschreibung
Zusammenfassung:	Familial hypercholesterolemia is marked by very elevated low-density lipoprotein cholesterol levels and premature cardiovascular disease. This 20-year follow-up study showed that statin initiation during childhood in affected persons slowed the progression of carotid intima–media thickness and reduced the risk of cardiovascular disease in adulthood.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1816454