Relationship of oxidative stress in the resistance to imatinib in Tunisian patients with chronic myeloid leukemia: A retrospective study

Background This work aimed to evaluate oxidative stress in chronic myeloid leukemia (CML) patients treated with tunisian (IM) vs controls and in CML patients with resistance to IM vs patients without resistance to IM. Methods The study included 40 CML patients and 34 controls. Of 40 patients with CM...

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Veröffentlicht in:	Journal of clinical laboratory analysis 2020-02, Vol.34 (2), p.e23050-n/a, Article 23050
Hauptverfasser:	Ammar, Mariam, Ben Mahmoud, Lobna, Medhaffar, Moez, Ghozzi, Hanen, Sahnoun, Zouheir, Hakim, Ahmed, Mseddi, Malek, Elloumi, Moez, Zeghal, Khaled
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Advanced Oxidation Protein Products - blood Antineoplastic Agents - pharmacology Antioxidants Antioxidants - metabolism Ascorbic acid Ascorbic Acid - blood Binding sites Case-Control Studies Catalase Chronic illnesses Chronic myeloid leukemia Drug Resistance, Neoplasm - drug effects Endangered & extinct species Enzymes - blood Female Glutathione - blood Glutathione peroxidase Hematology Humans Hydrogen peroxide Imatinib Imatinib Mesylate - pharmacology imatinib resistance Kinases Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism Life Sciences & Biomedicine Male Malondialdehyde Malondialdehyde - blood Medical Laboratory Technology Middle Aged Mutation Myeloid leukemia Oxidants Oxidation Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Proteins Science & Technology Spectrophotometry Superoxide dismutase Targeted cancer therapy Treatment Outcome Tunisia
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Zusammenfassung:	Background This work aimed to evaluate oxidative stress in chronic myeloid leukemia (CML) patients treated with tunisian (IM) vs controls and in CML patients with resistance to IM vs patients without resistance to IM. Methods The study included 40 CML patients and 34 controls. Of 40 patients with CML, 26 patients were developed in resistance to IM. The oxidant/antioxidant markers were evaluated by spectrophotometric methods for all used samples. Results For CML patients, increased malondialdehyde (MDA) and advanced oxidation protein products (AOPP) levels were found compared to controls (P
ISSN:	0887-8013 1098-2825
DOI:	10.1002/jcla.23050