Advanced Wearable Microfluidic Sensors for Healthcare Monitoring

Wearable flexible sensors based on integrated microfluidic networks with multiplex analysis capability are emerging as a new paradigm to assess human health status and show great potential in application fields such as clinical medicine and athletic monitoring. Well‐designed microfluidic sensors can be attached to the skin surface to acquire various pieces of physiological information with high precision, such as sweat loss, information regarding metabolites, and electrolyte balance. Herein, the recent progress of wearable microfluidic sensors for applications in healthcare monitoring is summarized, including analysis principles and microfabrication methods. Finally, the challenges and opportunities for wearable microfluidic sensors in practical applications are discussed. Wearable microfluidic sensors enable sweat analysis for healthcare monitoring. Due to their utilization of soft material, unique structure, and precise fluid flow control, microfluidic sensors possess intrinsic flexibility and stretchability and are capable of capturing health information from skin surfaces. Herein, the materials, fabrication, working principles, and strategies of microfluidic sensors are reviewed, and perspectives on future development are discussed.