Effect of Stimulation of α2-Adrenergic Receptors on Action Potential of Working Cardiomyocytes in Rat Atrium

The study examined the effect of clonidine hydrochloride (10 —9 -10 —5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α 2 -adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the act...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2019-09, Vol.167 (5), p.603-605
Hauptverfasser:	Zefirov, T. L., Faskhutdinov, L. I., Ziyatdinova, N. I., Galieva, A. M., Zefirov, A. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Biomedicine Cell Biology Internal Medicine Laboratory Medicine Pathology
Online-Zugang:	Volltext
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Zusammenfassung:	The study examined the effect of clonidine hydrochloride (10 —9 -10 —5 М) on electrical activity of working cardiomyocytes in rat right atrium. Stimulation of α 2 -adrenergic receptor with clonidine changed electrical activity of the heart. All tested concentrations of the agonist lengthened the action potential and decreased the firing rate of cardiomyocytes in a dose-dependent manner. The maximum effects of clonidine were observed at concentration of 10 —5 М.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04579-w