Hypothyroidism to Graves' disease and late appearance of pretibial myxoedema

Hypothyroidism to Graves' disease and late appearance of pretibial myxoedema

On examination, he had oedema and retraction of his eyelids and an obvious tremor. 6 months earlier, he had been diagnosed with autoimmune hypothyroidism after he began to gain weight and complained of feeling tired: his thyroid-stimulating hormone (TSH) concentration was raised at 83 mIU/L (normal...

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Veröffentlicht in:The Lancet (British edition) 2019-10, Vol.394 (10206), p.1364-1364
Hauptverfasser: Bruinstroop, Eveline, Cairo, Irina, Drillenburg, Paul, van Dam, P Sytze
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Attenuation
Biopsy
Blood
Collagen
Dermis
Edema
Fibers
Graves' disease
Hyperthyroidism
Hypothyroidism
Laboratory tests
Menopause
Peroxidase
Skin
Thyroid
Thyroid gland
Thyroid-stimulating hormone
Thyroxine
Tremor
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Beschreibung
Zusammenfassung:On examination, he had oedema and retraction of his eyelids and an obvious tremor. 6 months earlier, he had been diagnosed with autoimmune hypothyroidism after he began to gain weight and complained of feeling tired: his thyroid-stimulating hormone (TSH) concentration was raised at 83 mIU/L (normal range 0·3–4·6), free thyroxine (T4) concentration was 5·9 pmol/L (normal range 10–23), and the antithyroid peroxidase antibody concentration was markedly elevated at 1488 IU/mL (normal level
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(19)32281-0