Ultrasound Molecular Imaging of Atherosclerosis With Nanobodies: Translatable Microbubble Targeting Murine and Human VCAM (Vascular Cell Adhesion Molecule) 1

OBJECTIVE:Contrast-enhanced ultrasound molecular imaging (CEUMI) of endothelial expression of VCAM (vascular cell adhesion molecule)-1 could improve risk stratification for atherosclerosis. The microbubble contrast agents developed for preclinical studies are not suitable for clinical translation. O...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2019-12, Vol.39 (12), p.2520-2530
Hauptverfasser:	Punjabi, Mukesh, Xu, Lifen, Ochoa-Espinosa, Amanda, Kosareva, Alexandra, Wolff, Thomas, Murtaja, Ahmed, Broisat, Alexis, Devoogdt, Nick, Kaufmann, Beat A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - diagnostic imaging Aorta, Thoracic - metabolism Atherosclerosis - diagnosis Atherosclerosis - metabolism Brachiocephalic Trunk - diagnostic imaging Brachiocephalic Trunk - metabolism Cells, Cultured Disease Models, Animal Endothelial Cells - metabolism Endothelial Cells - pathology Humans Mice Mice, Knockout Microbubbles Molecular Imaging - methods Ultrasonography - methods Vascular Cell Adhesion Molecule-1 - biosynthesis
Online-Zugang:	Volltext
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