Higher maternal embryonic leucine zipper kinase mRNA expression level is a poor prognostic factor in non-small-cell lung carcinoma patients

To elucidate potential prognostic significance of mRNA expression in non-small-cell lung carcinoma patients. A loop algorithm based on R software was used to select genes with the best prognostic value. Mantel–Haenszel method and functional enrichment analysis were used to perform this analysis. mRNA expression level in tumor tissue is significantly higher than that in normal/benign tissue (p < 0.001), and gradually increases from stage I to IV (lung adenocarcinoma: p = 0.011; lung squamous cell carcinoma: p = 0.002), and is negatively correlated with prognosis in lung adenocarcinoma patients (HR: 2.025 in univariate analysis; HR: 2.162 in multivariate analysis). However, it does not show a significant correlation in lung squamous cell carcinoma patients. is a poor biomarker for non-small-cell lung carcinoma patients and can potentially be used as a therapeutic target.