The Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study: baseline participant profile

Objectives The aim of the study was to examine baseline neurocognitive impairment (NCI) prevalence and factors associated with NCI among patients enrolled in the Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study. Methods The NAMACO study is an ongoing, prospective, longitudi...

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Veröffentlicht in:HIV medicine 2020-01, Vol.21 (1), p.30-42
Hauptverfasser: Métral, M, Darling, KEA, Locatelli, I, Nadin, I, Santos, G, Brugger, P, Kovari, H, Cusini, A, Gutbrod, K, Tarr, PE, Calmy, A, Lecompte, TD, Assal, F, Monsch, A, Kunze, U, Stoeckle, M, Schwind, M, Schmid, P, Pignatti, R, Di Benedetto, C, Du Pasquier, R, Cavassini, M, Cavassini, Matthias, Du Pasquier, Renaud, Métral, Mélanie, Simioni, Samanta, Brugger, Peter, Gutbrod, Klemens, Monsch, Andreas U., Kunze, Ursi, Schneitter, Marianne, Nadin, Isaure, Früh, Severin, Schwind, Marc, Pignatti, Riccardo, Clarke, Stefanie, Assal, Frédéric, Derfuss, Tobias, von Arx, Sebastian, Eisele, Günter, Sacco, Leonardo, Bertschi, Manuel, Hundsberger, Thomas, Calmy, Alexandra, Lecompte, Thanh Doco, Hauser, Christoph, Cusini, Alexia, Weber, Rainer, Kovari, Helen, Hasse, Barbara, Tarr, Philip, Stoeckle, Marcel, Fux, Christoph, Bernasconi, Enos, Di Benedetto, Caroline, Bruno, Alessandra, Schmid, Patrick, Darling, Katharine, Scherrer, Alexandra, Vallet, Yannick, Alves, Deolinda, Locatelli, Isabella, Decosterd, Laurent, Granziera, Cristina, Krueger, Gunnar, Meuli, Reto, Vargas, Maria
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Sprache:eng
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Zusammenfassung:Objectives The aim of the study was to examine baseline neurocognitive impairment (NCI) prevalence and factors associated with NCI among patients enrolled in the Neurocognitive Assessment in the Metabolic and Aging Cohort (NAMACO) study. Methods The NAMACO study is an ongoing, prospective, longitudinal, multicentre and multilingual (German, French and Italian) study within the Swiss HIV Cohort Study. Between 1 May 2013 and 30 November 2016, 981 patients ≥ 45 years old were enrolled in the study. All underwent standardized neuropsychological (NP) assessment by neuropsychologists. NCI was diagnosed using Frascati criteria and classified as HIV‐associated or as related to other factors. Dichotomized analysis (NCI versus no NCI) and continuous analyses (based on NP test z‐score means) were performed. Results Most patients (942; 96.2%) had viral loads
ISSN:1464-2662
1468-1293
DOI:10.1111/hiv.12795