Performance evaluation of an Indoxyl Sulfate Assay Kit “NIPRO”

Performance evaluation of an Indoxyl Sulfate Assay Kit “NIPRO”

Background The relationship between renal disease and cardiovascular disease (CVD) is currently known as cardiorenal syndrome. Indoxyl sulfate (IS) is one of the uremic toxins that accelerates the progression of cardiorenal syndrome. This report presents a new method for measuring IS in a simpler wa...

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Veröffentlicht in:Clinical chemistry and laboratory medicine 2019-10, Vol.57 (11), p.1770-1776
Hauptverfasser: Fushimi, Yuki, Tatebe, Junko, Okuda, Yuko, Ishii, Toshiaki, Ujiie, Shinji, Morita, Toshisuke
Format: Artikel
Sprache:eng
Schlagworte:
analytical performance
Assaying
Biological Assay - methods
cardiorenal syndrome
Cardiovascular diseases
Coefficient of variation
Dilution
Heart diseases
High performance liquid chromatography
Humans
indoxyl sulfate
Interference
Linearity
Liquid chromatography
Mathematical analysis
Performance evaluation
Quantitation
Recovery
Sulfates
Toxins
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Zusammenfassung:Background The relationship between renal disease and cardiovascular disease (CVD) is currently known as cardiorenal syndrome. Indoxyl sulfate (IS) is one of the uremic toxins that accelerates the progression of cardiorenal syndrome. This report presents a new method for measuring IS in a simpler way. Methods We evaluated the analytical performance of an IS Assay Kit "NIPRO" loaded on LABOSPECT 008. The evaluated analytical performances included accuracy, precision, dilution linearity, limit of detection (LOD), limit of quantitation (LOQ), recovery test, interference test and comparison against assays performed by high-performance liquid chromatography (HPLC). Results Total precision showed a
ISSN:1434-6621
1437-4331
DOI:10.1515/cclm-2019-0218